Fumitremorgin C

Name	Fumitremorgin C
Synonyms	Fumitremorgin C 12α-Fumitremorgin C 12alpha-Fumitremorgin C FuMitreMorgin CFuMitreMorg Fumitremorgin C, from Aspergillus fumigatus
CAS	118974-02-0

Molecular Formula	C22H25N3O3
Molar Mass	379.45
Density	1.34±0.1 g/cm3(Predicted)
Melting Point	259.5-260.5℃
Boling Point	642.9±55.0 °C(Predicted)
Solubility	DMSO
Appearance	solid
pKa	17.16±0.40(Predicted)
Storage Condition	2-8°C
In vitro study	Multidrug resistance (MDR) is a major problem in cancer chemotherapy. Fumitremorgin C is extremely effective in reversing resistance to mitoxantrone, doxorubicin, and topotecan in multidrug-selected cell lines. In MCF-7/mtxR (a mitoxantroneselected cell line), fumitremorgin C reverses mitoxantrone resistance (114-fold) and doxorubicin resistance (3-fold). Fumitremorgin C (5/AM)significantly potentiates the toxicity of mitoxantrone (93-fold), doxorubicin (26-fold), and topotecan (24-fold) in S1M1-3.2 cells. Reversal of resistance is associated with an increase in drug accumulation. Fumitremorgin C does not reverse drug resistance in cells with elevated expression of Pgp or MRP. Fumitremorgin C almost completely reverses resistance mediated by BCRP in vitro and is a pharmacological probe for the expression and molecular action of this transporter. Fumitremorgin C also enhances the toxicity of mitoxantrone and topotecan in vector-transfected MCF-7 cells (2.5–5.6 fold). It reduces the IC 50 of topotecan in BCRP-overexpressing cells below that observed in the untreated vector-transfected cells. .

Safety Description	S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes.
WGK Germany	3

Background	Aspergillus fumigatus toxin is produced by Fusarium moniliforme and is commonly found in moldy corn, mycotoxins. Aspergillus fumigatus toxin was found late, the earliest report in 1988, the most common is Aspergillus fumigatus toxin B, Aspergillus fumigatus toxin C.
biological activity	Fumitremorgin C is a potent, selective inhibitor of ABCG2/BRCP.

Last Update：2024-04-09 21:54:55

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